Selectivity · by receptor
MC2R: ligand selectivity
Melanocortin 2 receptor · adrenal · cortisol
1 catalogued melanocortin ligand binds MC2R with a curated affinity. The tightest is ACTH (≈0.16 nM). The most MC2R-selective is ACTH, which prefers MC2R by 16× — because the five receptors share one binding core, a ligand that truly prefers MC2R is the exception, not the rule.
Most MC2R-selective
Ligands whose tightest target of the five receptors is MC2R — ranked by selectivity window (how cleanly they prefer it).
- ACTH16×Selective
Everything that binds MC2R
Ranked by binding strength. Filled bars are agonists; blue bars are blockers. Select a ligand for its full fingerprint across all five receptors.
Binding is not the whole story: these bars show how tightly each ligand holds MC2R, not what the receptor then does once bound. For the receptor's own biology — where it sits, what it controls, and what breaks when it fails — see the MC2R page. To put any one ligand next to the others, use the selectivity visualizer; for every value with its citation, the binding matrix.
Affinity values from the IUPHAR/BPS Guide to PHARMACOLOGY; selectivity is derived from them. Educational resource, not medical advice — see the editorial standards.