.pomc-tree[data-astro-cid-cjua25pq]{margin:0;padding:0;list-style:none}.pomc-subtree[data-astro-cid-cjua25pq]{margin:0;padding-left:.5rem;list-style:none}.pomc-subtree[data-astro-cid-cjua25pq]>li[data-astro-cid-cjua25pq]{padding-left:1.4rem;position:relative}.pomc-subtree[data-astro-cid-cjua25pq]>li[data-astro-cid-cjua25pq]:before{content:"";border-left:1.5px solid var(--border);position:absolute;top:0;bottom:0;left:0}.pomc-subtree[data-astro-cid-cjua25pq]>li[data-astro-cid-cjua25pq]:after{content:"";border-top:1.5px solid var(--border);width:1rem;position:absolute;top:1.5rem;left:0}.pomc-subtree[data-astro-cid-cjua25pq]>li[data-astro-cid-cjua25pq]:last-child:before{height:1.5rem;bottom:auto}li[data-astro-cid-cjua25pq]{margin-top:.5rem}.pomc-tree[data-astro-cid-cjua25pq]>li[data-astro-cid-cjua25pq]{margin-top:0}.pomc-node[data-astro-cid-cjua25pq]{text-align:left;cursor:pointer;background:var(--bg-elevated);border:1px solid var(--border);width:100%;max-width:30rem;color:inherit;border-left-width:3px;border-radius:.55rem;grid-template-columns:auto 1fr;align-items:baseline;gap:.1rem .6rem;padding:.55rem .8rem;transition:border-color .15s,background-color .15s,opacity .2s;display:grid}.pomc-node[data-astro-cid-cjua25pq]:hover{border-color:var(--accent);background:var(--accent-soft)}.pomc-node[data-astro-cid-cjua25pq]:focus-visible{outline:2px solid var(--accent);outline-offset:2px}.cls-precursor[data-astro-cid-cjua25pq]{border-left-color:var(--text-muted)}.cls-intermediate[data-astro-cid-cjua25pq]{border-left-color:var(--color-ink-400,var(--text-muted))}.cls-melanocortin[data-astro-cid-cjua25pq]{border-left-color:var(--accent)}.cls-opioid[data-astro-cid-cjua25pq]{border-left-color:var(--color-pigment-300,var(--accent))}.cls-other[data-astro-cid-cjua25pq]{border-left-color:var(--border)}.enz[data-astro-cid-cjua25pq]{font-family:var(--font-mono,monospace);letter-spacing:.02em;white-space:nowrap;border-radius:.3rem;grid-row:1/span 2;align-self:center;padding:.12rem .4rem;font-size:.62rem;font-weight:600}.enz-pc1[data-astro-cid-cjua25pq]{background:var(--surface,#ecebe7);color:var(--text-muted)}.enz-pc2[data-astro-cid-cjua25pq]{background:var(--accent-soft);color:var(--accent-strong)}.pomc-name[data-astro-cid-cjua25pq]{font-size:.98rem;font-weight:600;line-height:1.2}.pomc-tag[data-astro-cid-cjua25pq]{color:var(--text-muted);grid-column:2;font-size:.75rem;line-height:1.2}.pomc-tree.no-pc2 li[data-astro-cid-cjua25pq][data-pc2=true]>.pomc-node[data-astro-cid-cjua25pq]{opacity:.4;filter:grayscale(.5)}.pomc-tree.no-pc2 li[data-astro-cid-cjua25pq][data-pc2=true]>.pomc-node[data-astro-cid-cjua25pq] .pomc-name[data-astro-cid-cjua25pq]{text-decoration:line-through 1px}.pomc-node[data-astro-cid-cjua25pq].sel{border-color:var(--accent);background:var(--accent-soft);box-shadow:0 0 0 1px var(--accent)}.tissue-btn[data-astro-cid-rdhvgwsh]{border:1px solid var(--border);background:var(--bg-elevated);color:inherit;cursor:pointer;text-align:left;border-radius:.55rem;flex-direction:column;align-items:flex-start;gap:2px;padding:.5rem .9rem;transition:border-color .15s,background-color .15s;display:flex}.tissue-btn[data-astro-cid-rdhvgwsh]:hover{border-color:var(--accent)}.tissue-btn[data-astro-cid-rdhvgwsh][aria-pressed=true]{border-color:var(--accent);background:var(--accent-soft)}.tissue-enz[data-astro-cid-rdhvgwsh]{font-family:var(--font-mono);color:var(--text-muted);font-size:.68rem}.tissue-btn[data-astro-cid-rdhvgwsh][aria-pressed=true] .tissue-enz[data-astro-cid-rdhvgwsh]{color:var(--accent-strong)}.pomc-legend[data-astro-cid-rdhvgwsh] li[data-astro-cid-rdhvgwsh]{align-items:center;gap:7px;display:flex}.swatch[data-astro-cid-rdhvgwsh]{background:var(--bg-elevated);border-left:3px solid;border-radius:3px;width:12px;height:12px;display:inline-block}.swatch[data-astro-cid-rdhvgwsh].cls-melanocortin{border-left-color:var(--accent)}.swatch[data-astro-cid-rdhvgwsh].cls-intermediate{border-left-color:var(--color-ink-400)}.swatch[data-astro-cid-rdhvgwsh].cls-opioid{border-left-color:var(--color-pigment-300)}.swatch[data-astro-cid-rdhvgwsh].cls-other{border-left-color:var(--border);border:1px solid var(--border)}.enz-key[data-astro-cid-rdhvgwsh]{font-family:var(--font-mono);border-radius:.3rem;padding:.12rem .4rem;font-size:.62rem;font-weight:600}.enz-key[data-astro-cid-rdhvgwsh].enz-pc1{background:var(--surface,#ecebe7);color:var(--text-muted)}.enz-key[data-astro-cid-rdhvgwsh].enz-pc2{background:var(--accent-soft);color:var(--accent-strong)}.prose-body[data-astro-cid-rdhvgwsh] a[data-astro-cid-rdhvgwsh]{text-underline-offset:2px;text-decoration:underline dotted}.prose-body[data-astro-cid-rdhvgwsh] a[data-astro-cid-rdhvgwsh]:hover{color:var(--accent)}